Nature Metabolism

Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity

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Frontiers in Pharmacology

Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport

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Journal of Controlled Release

Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice

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Society of Biological Psychiatry (SOBP) 2024

A First-in-Human Phase 1 Study of SPT-300, a First-in-Class Orally Bioavailable Prodrug of the NeurosteroidAllopregnanolone That is Absorbed via the Lymphatic System

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Society of Biological Psychiatry (SOBP) 2024

SPT-300, an Oral Prodrug of Allopregnanolone, Potently Reduces Salivary Cortisol Response to the Trier Social Stress Test in a Randomized, Placebo-Controlled Phase 2a Study in Healthy Participants

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Society of Biological Psychiatry (SOBP) 2024

SPT-300, a First-in-Class Orally Bioavailable Prodrug of the Neurosteroid Allopregnanolone: Safety, Tolerability, and Clinical Pharmacology in Healthy Volunteers

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